Endocrine Abstracts

Recent studies have reported that tissue micro-environment including tumor infiltrating lymphocytes (TILs) as well as neo-angiogenesis played pivotal roles in biological and clinical behavior of various human malignancies. In adrenal neoplasms, TILs are far more frequently detected in cortical than medullary tumors. In adrenocortical adenomas, we have recently demonstrated that enhanced angiogenic chemokines, especially CXCL12, in cortisol producing adenoma (CPA), induced TILs...

Introduction: While a great degree of focus has recently been placed on identifying novel steroidogenic pathways that are active in cancer development (e.g. Androgen metabolism and Androgen Receptor (AR) Signalling, Glucocorticoid Metabolism and Glucocorticoid receptor (GR) signalling) very few studies have examined these pathways in normal breast samples taken under non-pathological conditions. Furthermore, very few studies have examined the steroid levels in non-pathological...

Peripheral 18-oxocortisol level could contribute to the detection of aldosterone-producing adenoma in patients with primary aldosteronism. However, peripheral 18-oxocortisol varies among such patients, which is a big drawback concerning its clinical application. We studied 48 cases of aldosterone-producing adenoma, 35 harboring KCNJ5 mutation, to clarify the significance of clinical and pathological parameters regarding peripheral 18-oxocortisol. Peripheral 18-oxocort...

Introduction: Aging is associated with the pathogenesis of many endocrinological disorders, especially for functioning adrenocortical disorders. In addition, mitochondria DNA abnormalities have been reported to be correlated with aging through ROS which eventually resulted in cell senescence. We previously reported that cortisol-producing adenomas (CPA) expressed more abundant cell senescent markers including p16 and p21, compared to other hormone-producing adenomas. However, ...

Introduction: Pheochromocytoma and paraganglioma (PPGL) are rare endocrine tumors with few effective treatment options for malignant cases. Novel therapeutic indications, such as 177Lu-DOTA-TATE and immune checkpoint inhibitors (ICIs) for patients with PPGL, have been investigated in several clinical trials. Emerging evidence shows that somatostatin receptor 2 (SSTR2) in other cancer types correlates with the tumor microenvironment (TME) activation and could be a predictive bi...

The pathophysiology of aldosterone-producing adenomas (APA), especially those manifesting clinically overt hyperaldosteronism despite their small size, remains unknown. Therefore, we examined the correlation between tumor size and the status of intratumoral steroidogenic enzymes involved in aldosterone biosynthesis using immunohistochemistry. Forty patients with surgically proven APAs following adrenal venous sampling were retrospectively studied. The tumor area at the maximum...